It breaks my heart, he battled depression for much of his life and spent so long suffering. His own experience with mental illness is what enabled him to write such insightful works about people suffering in their own minds.
His books had such a great impact upon so many people, myself included. "It's Kind of a Funny Story" as well as Ned's autobiography helped me through a period of depression.
I had a brief interaction with Mr. Vizzini when my mother took a picture of me purchasing his new book "The Other Normals" and sent it to him on twitter. Ned replied cheerfully and thanked me for the photograph. That simple thing made me nearly cry tears of joy, I respect him so much and found such solace in his works that the fact I myself gave him any measure of happiness brings tears to my eyes. When I cried to my mother upon learning the news of his death, she held me and reminded me of a line from an episode of Doctor Who. "Life's a pile of good and bad things, the bad things don't necessarily cancel out the good things, and you definitely added to his pile of good things."
Mr. Vizzini you saved so many people from a horrible fate, it kills me that you couldn't save yourself. You will be missed by many, I wish you'd had longer on this Earth. I wish the best for your wife and kids. Rest in peace you poor lost soul.